[Summary text]
Skal allergen-specifik immunterapi bruges for at forebygge astma hos børn med allergisk rhinoconjunctivitis udløst af pollen?
Symptomscorer (kritisk)
Medicinscorer (kritisk)
Udvikling af astma (kritisk)
Anafylaksi (kritisk)
Livskvalitet (vigtig)
Fraværsdage fra arbejde/skole (vigtig)
Study design: Randomized controlled trial
Study grouping: Parallel group
Open Label: YES
Cluster RCT:
Baseline Characteristics
SIT
Control
Included criteria: clinical history of rhinitis, Birch or grass pollen season or bothpositive skin prick test Birch, grass or bothpositive conjunctival provocation, bric, grass or both
Excluded criteria: other clinical inhalation allergiesprevious SITasthma symptoms and need for daily treatment
Intervention Characteristics
SIT
Control
Continuous:
Dichotomous:
Sponsorship source:
Country: Germany
Setting:
Comments:
Authors name: Niggemann B
Institution: Department of pediatric pneumology and immunology, Charité, Berlin
Email:
Address:
Identification:
Participants:
Study design:
Baseline characteristics:
Intervention characteristics:
Pretreatment:
Kirsten Skamstrup Hansen only data on data from all 6 centres at baseline time point '0'
Continuous outcomes:
Dichotomous outcomes:
Adverse outcomes:
Selection bias (biased allocation to interventions) due to inadequate generation of a randomised sequence
Comment: not stated
Selection bias (biased allocation to interventions) due to inadequate concealment of allocations prior to assignment
Comment: concealment not statedstratification for relevant parametres included
Performance bias due to knowledge of the allocated interventions by participants and personnel during the study
Comment: unbliinded study
Detection bias due to knowledge of the allocated interventions by outcome assessors
Comment: unblinded studyno data on weather the data management was performed blinded
Attrition bias due to amount, nature or handling of incomplete outcome data
Comment: No data but very few drop-outs.
Reporting bias due to selective outcome reporting
Comment: unblinded studyno data on excluded patientsno data on side-effects?
Bias due to problems not covered elsewhere in the table
Comment: relatively small groups